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4-Star and Above Hotels in Panama City for Memorial Day Weekend
Panama City offers a range of upscale accommodations, including 4-star and higher hotels that typically feature luxurious amenities such as pools, spas, and fine dining options. Visitors can expect to enjoy vibrant nightlife, cultural experiences, and easy access to major attractions like the Panama Canal and Casco Viejo.
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85% Match










JW Marriott Panama
Calle Punta Colon, Punta Pacífica, Panama City

Storied Collection:
luxury
family-friendly
ocean views
This luxurious hotel offers **spacious modern rooms** with private balconies and ocean views, perfect for a relaxing Memorial Day weekend. Enjoy the **infinity pools** and diverse dining options that cater to families and couples alike.... Read more
8.8
Very Good
(1043 reviews)
Matched amenities:
Restaurant
Pets allowed
Room service
Meeting/banquet facilities
Bar
90% Match










Hilton Panama
Av. Balboa con calle Aquilino de la Guardia, Panama City

Storied Collection:
4-Star
Convenient Location
Comfortable Rooms
This hotel is a fantastic choice for your Memorial Day Weekend with its **24-hour front desk** and **luggage storage** facilities, ensuring a hassle-free stay. Enjoy the comfort of well-equipped rooms and the convenience of being close to major attractions in Panama City.... Read more
8.6
Very Good
(856 reviews)
Matched amenities:
Restaurant
Room service
Meeting/banquet facilities
Bar
24-hour front desk
85% Match










Riu Plaza Panamá
Calle 50 con 53 Este, Marbella, Panama City

Storied Collection:
outdoor pool
dining options
business district
This hotel is perfect for your Memorial Day Weekend with its **outdoor pool** and vibrant dining options like the Sushi Lounge and Ibiza Lounge. Located in the business district, it offers stylish rooms and is just a short distance from local attractions.... Read more
8.7
Very Good
(10448 reviews)
Matched amenities:
Restaurant
Room service
Meeting/banquet facilities
Bar
24-hour front desk
90% Match










Bristol Panama, a Registry Collection Hotel
Calle Aquilino de la Guarida, Panama City

Storied Collection:
luxury
spa
city center
This hotel is a **5-star** establishment located in the heart of Panama City, perfect for a luxurious Memorial Day weekend. Enjoy top-notch **facilities** like a spa, fitness center, and gourmet dining options.... Read more
9.2
Wonderful
(1223 reviews)
Matched amenities:
Restaurant
Room service
Meeting/banquet facilities
Bar
24-hour front desk
85% Match










W Panama
Calle 50 and Aquilino de la Guardia, Panama City

Storied Collection:
5-star
outdoor pool
dining options
This hotel offers **5-star** accommodation with a vibrant atmosphere, perfect for a Memorial Day Weekend getaway. Enjoy the outdoor pool and multiple dining options, making it an ideal choice for relaxation and entertainment.... Read more
8.6
Very Good
(610 reviews)
Matched amenities:
Restaurant
Pets allowed
Room service
Meeting/banquet facilities
Bar
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