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4-star hotels in Rome for 2 adults from Oct 7 to Oct 10, 2025

Rome offers a variety of 4-star hotels that provide luxurious amenities such as spa services, fine dining, and proximity to historic landmarks like the Colosseum and Vatican City, ideal for adult travelers seeking comfort and cultural experiences.
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Nomos Hotel
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pin
Via di San Paolo alla Regola, 3, 00186 Rome
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Storied Collection:
5-star
central location
restaurant
This 5-star hotel in the centre of Rome offers **air-conditioned rooms**, a **restaurant**, and a **bar**, making it an excellent choice for a comfortable and convenient stay. Its location near popular attractions like Campo de' Fiori and Pantheon adds to its appeal for travelers wanting to explore the city.... Read more
9.8
Wonderful
(18 reviews)
Matched amenities:
RestaurantRestaurant
Room serviceRoom service
BarBar
24-hour front desk24-hour front desk
Non-smoking roomsNon-smoking rooms
Lowest price
39% off
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/night
Available from:Oct 7-10
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The Goethe Hotel - Small Luxury Hotels of the World
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pin
Via del Fiume, 14, 00186 Rome
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Storied Collection:
5-star
spa
central location
This 5-star hotel in Rome offers **luxurious accommodation** with a spa and wellness centre, perfect for a relaxing stay. Its location near popular attractions like Piazza di Spagna and Via Condotti makes it ideal for exploring the city.... Read more
9.4
Wonderful
(55 reviews)
Matched amenities:
RestaurantRestaurant
Room serviceRoom service
BarBar
24-hour front desk24-hour front desk
Non-smoking roomsNon-smoking rooms
Lowest price
Booking
/night
Available from:Oct 7-10
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Fortyfive Squared Hotel
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pin
Piazza Indipendenza 13, 00185 Rome
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Storied Collection:
4-star
central location
free WiFi
This 4-star hotel in Rome offers **convenient location** just 500 metres from Rome Termini Train Station, making it easy to explore the city. It features excellent facilities including a **bar**, **buffet breakfast**, **free WiFi**, and **airport transfers**, ideal for a comfortable stay for two adults.... Read more
Lowest price
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/night
Available from:Oct 7-10
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Numa Rome Trastevere
starstarstarstar
pin
Via Luigi Turchi, 9, 00153 Rome
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Storied Collection:
4-star
Rome
kitchen
This hotel in Rome offers **4-star accommodation** with modern amenities including a fully equipped kitchen, air conditioning, and free WiFi, making it ideal for a comfortable stay. Its location in Trastevere provides easy access to key attractions like the Roman Forum and Campo de' Fiori, perfect for exploring the city.... Read more
9.2
Wonderful
(36 reviews)
Matched amenities:
Non-smoking roomsNon-smoking rooms
Family roomsFamily rooms
Internet servicesInternet services
LiftLift
Express check-in/check-outExpress check-in/check-out
Lowest price
Booking
/night
Available from:Oct 7-10
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Cunabu Emilio
starstarstarstar
pin
Via Paolo Emilio, 57 Piano Secondo, Interno 12, 00192 Rome
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Storied Collection:
4-star
central location
air conditioning
This 4-star hotel in the centre of Rome offers **air-conditioned rooms** with modern amenities like flat-screen TVs and free WiFi, making it comfortable for your stay. Its location near Lepanto and Ottaviano Metro Stations provides easy access to major attractions such as the Vatican Museums and St Peter's Square, ideal for exploring Rome.... Read more
7.9
Good
(32 reviews)
Matched amenities:
Non-smoking roomsNon-smoking rooms
Family roomsFamily rooms
Internet servicesInternet services
LiftLift
Express check-in/check-outExpress check-in/check-out
Lowest price
Booking
/night
Available from:Oct 7-10
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