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Budget to midrange hotels near I-95 from Gainesville, FL to Lyme, NH (July 2025)

The route from Gainesville, Florida to Lyme, New Hampshire along I-95 passes through several states with a variety of budget to midrange hotels close to the highway. Accommodations typically offer convenient access to I-95, free WiFi, parking, and basic amenities suitable for a comfortable overnight stay during a road trip. Key stopover cities include Savannah, GA and the Washington, DC area, where travelers can find hotels that balance affordability and comfort.
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Best Western Gateway Grand
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4200 North West 97th Boulevard, Gainesville FL 32606
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8.2
Very Good
(1374 reviews)
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Available from:Jul 10-12
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HoM, A Trademark Collection Hotel
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3905 Sw 43rd Street, Gainesville 32608
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8.0
Good
(911 reviews)
Lowest price
15% off
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Available from:Jul 10-12
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Quality Inn Gainesville I-75
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3455 Southwest Williston Road, Gainesville FL 32608
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7.1
Good
(395 reviews)
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Available from:Jul 10-12
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Drury Inn & Suites Gainesville
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4000 Southwest 40th Blvd, Gainesville FL 32608
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9.3
Wonderful
(1226 reviews)
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/night
Available from:Jul 10-12
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Holiday Inn Express & Suites - Gainesville I-75 by IHG
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3370 SW 42nd Street, Gainesville 32608
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9.1
Wonderful
(553 reviews)
Lowest price
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/night
Available from:Jul 10-12
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